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It is unclear to what extent the reduction in lean mass is attributable to loss of skeletal muscle mass per se, which comprises only one component of total body lean mass in mice, but the lack of effect on fat mass is consistent with the reported paucity of IGF-1Rs on mature adipocytes
Whether this should be regarded as specific metabolic treatment, targeting only the metabolic alterations of the syndrome, is debatable, since the improvement in metabolic conditions, e.g., insulin resistance, would tenably have a positive impact also in gonadal function in women with PCOS
Indeed, the association of doxorubicin with bioenergetic toxicity is well stated in the literature 32,33,34
The 28-day countdown begins only after the first rubber stopper puncture
Clinical trials show weight loss averaging 1522% of body weight over 68 weeks, far exceeding the effects of SGLT2 inhibitors alone
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