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Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
No regulatory authority Health Canada, the FDA, the EMA, the TGA, or any equivalent has cleared either component peptide, or the blend formulation, as a drug for human or veterinary use
Vitamin b12 injection for dogs enters the systemic circulation and shows quick effects after the administration
While this effect has been primarily observed in the GI tract, there is evidence for similar benefit in cardiovascular, neurological, and muscle tissues, suggesting that BPC-157 may be used as both a therapy in the setting of stroke and heart attack as well as a probative peptide for understanding how to promote healing following ischemic injury [5], [6]
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Combining these peptides addresses wound healing from multiple angles: the structural matrix, the cellular migration to fill it, and the blood vessel development to support it
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