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While the exact causes of these erythrocyte changes are due to fibrin amyloid microclots or other factors, such as ROS (which can cause RBC changes as well [367, 368]), remain unclear, they likely contribute to the oxidative stress observed in Long COVID [369, 370]

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According to some publications, the extent and the intensity of physiological oral mucosal melanin hyperpigmentation increase with age probably owing to the cumulative effects of endogenous and extrinsic melanogenic stimuli, such as inflammatory processes, drugs, tobacco smoke, and recurrent minor functional injuries [4, 6, 11, 13]

Carnitine plays a vital role in transporting fatty acids into the mitochondria of the cell where they are burnt for energy, and research has shown that more carnitine in the muscle results in body fat being used as an energy source during exercise

Currently, excessive NNMT upregulation is implicated in several scenarios, including obesity, metabolic diseases, muscle cell degeneration, and even some types of cancer [2, 4]

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