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All of these approaches are valid

2006;129(Pt 11):28562866

are on a patent application held by the Feinstein Institutes for Medical Research (FIMR) related to the azapeptide synthesis platform-Preparation of O-benzotriazole and O-imidazole synthons for use in the synthesis of peptidomimetics including azapeptides, WO2020227594 A1 2020-12-11 (active)

Hence, while the complete picture of how the combination works is still unclear, there is evidence supporting that it entails common signaling pathways

Adequate fat intake: Fat stimulates bile release, which has a natural laxative effect

Rapid weight loss may not be appropriate for all individuals with BED, particularly those without obesity