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Aditi Kantipuly and (the other) Peter Singer made the case in STAT in March 2026: BMI thresholds derived from American populations miss obesity in Asian patients, who face greater cardio-metabolic risk at lower BMI

Critical preclinical studies in animals Building on this foundation, many drugs were developed targeting this pathway, such as liraglutide and semaglutide (including Ozempic and Wegovy) helping millions of people manage diabetes and achieve healthy weight loss

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Without insurance, most patients cannot afford them, even though they may be medically necessary

and that any discrepancies from the study as originally planned (and, if relevant, registered) have been explained

If weight loss feels harder after 40, youre not imagining it