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Acetylcarnitine can up-regulate the expression of voltage-dependent anion channel gene in rat brain, which plays an important role in synaptic plasticity [110]
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Downregulation of ATP5A1, the ATP Synthase F1 Subunit Alpha [123], and ATP5G3, the ATP synthase F0 complex subunit C3 [124], was observed in the postmortem study of ASD patients in all examined regions [122], which could inhibit the activity of complex V [79] and promote the ETC breakdown due to opening of the mPTP [125, 126]
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This capability is critical for uncovering disease mechanisms and discovering novel biomarkers [278, 279]
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