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doi:10.1001/jama.2021.1831 10.A Research Study to See How Semaglutide Helps People With Excess Weight, Lose Weight (STEP UP) (STEP UP)

Individuals with kidney disease, cystinosis, or metabolic disorders should consult providers before starting

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If you have diabetes, check your blood or urine ketones when glucose readings are high or if you're experiencing symptoms of hyperglycemia

According to American Diabetes Association guidelines, diabetes is diagnosed when A1C 6.5%, fasting plasma glucose 126 mg/dL, 2-hour plasma glucose 200 mg/dL during an oral glucose tolerance test, or random plasma glucose 200 mg/dL with classic symptoms