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Additionally, while drugs like SGLT2 inhibitors and GLP-1 receptor agonists have demonstrated benefits in improving cardiac function and glucose metabolism in patients with DCM (107, 108, 111, 113), their side effects present significant limitations in clinical practice
With an excess of reducing equivalents, T cells are unable to activate the relevant redox kinases, which allows them to bypass the regulatory checkpoints of the G2/M cell cycle and enter unrestrained proliferation ( Macrophages from RA patients have high mitochondrial activity and can efficiently generate ROS ( Figure 2 )
PMID 18979624
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