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Often referred to as the "master antioxidant," glutathione plays a central role in detoxification, immune defense, and protecting cells from oxidative stress

Placental melatonin system is present throughout pregnancy and regulates villous trophoblast differentiation

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While multiple advantageous aspects of the metabolic reprogramming for NRF2-addicted cancer cells have been described, metabolic liabilities resulting from NRF2-dependent reprogramming have also been investigated