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Tirzepatide occupies the middle ground: broader than classical GLP-1 analogues, but more selective than triple agonists

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(PubMed) Henkin RI, Patten BM, Re PK, Bronzert DA

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18,23,123 The prototypical example of a genetic primary astrocytopathy is Alexander disease, a leukomalacia in which astrocytes express mutant GFAP, although how the expression of this mutant gene translates into severe damage of the white matter remains unknown