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In the context of fear-conditioning training, rapid demethylation of Reelin already occurred within 1 h and this demethylation event was essential for the transcriptional activation of Reelin and memory formation

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Glutamate levels, crucial for cognition, memory, and learning, are reduced in the model group, implying an adverse effect on brain function

however, dedicated cardiovascular outcome trial (CVOT) data have not yet been published, and cardiovascular benefit has not been demonstrated Phase 3 trials are ongoing

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