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Ethics statement The studies involving human participants were reviewed and approved by IRB-20220254-R

Mens Health 37 (2), 166174

2025 Aug 23;17(1):352

10.1073/pnas.93.15.7923 Proc

GPX4 is the only cellular enzyme that specifically reduces phospholipid hydroperoxides to lipid alcohols using GSH as a co-factor 4 , and inhibiting the cyst(e)ine/GSH/GPX4 axis induces the strongest cell death in most cellular contexts