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Most safety information comes from preclinical animal studies and practitioner experience reports

Common Side Effects Water Retention Growth hormone causes sodium and water retention as part of its physiologic activity

Inhibition of glutathione disulfide reductase by glutathione

Human clinical-trial data (Phase 1/2 studies in wound healing, cardiac injury, and dry eye) exist only for a different, full-length recombinant thymosin beta-4 product, not for the short synthetic fragment marketed as TB-500, so no completed published human trial has evaluated TB-500 specifically for muscle, tendon, or joint recovery

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Any references to tissues, cells, or pathways are provided for research context only and do not imply therapeutic or clinical use