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Nature 533 (7602), 274277

The risk is higher if you also take diabetes medicines like insulin or sulfonylureas (such as glipizide, glimepiride, or glyburide)

Extracellular aggregates of A amyloid protein and phosphorylated tau protein are common pathological deposits in the brains of Alzheimers patients

doi:10.1136/jcp.42.6.624

It works through a different mechanism than diet and exercise alone, making it valuable for people with hormonal or metabolic factors contributing to weight gain.