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The main signaling pathways downstream of the IGF-1 receptor are Ras/MAPK and PI3K/Akt, while these two pathways are responsible for the glucose and lipid metabolism in the liver ( Crosstalk Between Circadian Clock System and GH/IGF-1 Axis Regulatory Effect of the GH/IGF-1 Axis on the Circadian Clock System There are very few reports to identify the regulatory effect of the GH/IGF-1 axis on the circadian clock system

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Glutathione stabilizes the inner mitochondrial membrane, squelches reactive oxygen species (ROS) generated by mitochondrial respiration, and maintains mitochondrial DNA fidelity to profoundly influence mitochondrial function and cell survival

Importantly, CR can generate rapid effects (1 month) on the electron transport system (Chen et al., )

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Remove the mask pack when it becomes transparent