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Furthermore, recent evidence has indicated that some of the inflammation produced by intrarectal administration of TNBS may be mediated by a burst of ROS produced from its metabolism within the mucosal interstitium (Grisham et al, 1991)
May relate to blood pressure effects
In recent years, the question of whether there is a role for de-escalation of systemic neoadjuvant and adjuvant therapies has arisen
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