The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location
However, some peptides, such as semaglutide and tirzepatide, are FDA-approved for weight loss under brand names Wegovy and Zepbound, respectively
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If a peptide reduces mortality from 70 % to 10 %, that is an enormous effect