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It activates GLP-1 and GIP pathways to slow digestion, reduce appetite and food cravings, and improve blood sugar balance

2 Methods 2.1 Study design and search strategy The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines were referenced when conducting this systematic review and meta-analysis ( This strategy was applied across the PubMed-MEDLINE, Cochrane Library, and Embase databases for relevant studies using a combination of database-specific subject headings and keywords

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Avoid caffeine and high-fiber foods that may worsen diarrhea

If 10 mg produces excellent efficacy but borderline intolerable nausea, try 7.5 mg for 6 to 8 weeks to assess whether efficacy remains adequate with improved tolerability

Of course, even though the FDA banned it from one aisle of the drug store, it still may be available on another, in the form of tonic water