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On the other hand, the GPx enzyme detoxes peroxides using glutathione as a cofactor, while GR regenerates the reduced glutathione (8), so they act together to prevent oxidative injury and cell death mediated by reactive oxygen species (50)

Researchers suggest that this stimulation may lead to the overgrowth of cells covering smaller ducts, causing hyperplasia, increased pancreatic weight, duct occlusion, back pressure, and subsequent acute or chronic inflammation