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14 Although most vertebral fractures are clinically silent at first, they can eventually cause pain, disability, deformity, and mortality

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The guideline is designed as a living document that will be updated as new real-world and long-term evidence emerges. In effect, the WHO is saying: the benefits are real, but we must continue to study safety, durability, and what happens when treatment stops. Where there is evidence for GLP-1 efficacy and safety, the WHO notes that existing studies are at serious risk of bias and are of either low or very low quality