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(28152637) IV L-arginine might be a reasonable consideration in the following situations: i) Moderate to severe hyperammonemia, without immediate access to hemodialysis ii) Persistent hyperammonemia, despite hemodialysis iii) Hyperammonemia which poses an immediate threat to life (e.g., moderate to severe hyperammonemia with evidence of cerebral edema) A reasonable dose may be: (22642880) Loading bolus of 250 mg/kg (1.2 mM/kg) over 2 hours

Global obesity rates were 15% for women and 11% for men, based on Center estimates of WHO and World Bank data

One major deficiency of this model is that obesity, type II diabetes and the ensuing cardiac phenotypes develop rather early in life compared to human patients

Diabetes 61: 364-371, 2012

Int J Mol Sci 22:11677