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These cells release the recruiting chemokine CCL-2
Chronic cases may require a full 12-week cycle and occasionally a second cycle after a break to reach the target endpoint
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These alterations precede any observable weight gain but could contribute to the mechanisms of impaired insulin signaling (Matsuzawa-Nagata et al., 2008), which could ultimately lead to the development of type 2 diabetes (Wang et al., 2003), as well as other metabolic disorders (Lumeng and Saltiel, 2011)
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