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In experimental animal models, GIPR agonists improved glycemia and prevented obesity from highfat diet

New GLP-1 pill helps patients lose up to 8% of body weight, trial shows Orforglipron led to greater weight loss than semaglutide tablets and could offer more effective oral alternative to jabs A new daily pill could be a more effective GLP-1 tablet for weight loss, according to a clinical trial that may pave the way for an improved non-injection alternative to Wegovy and Mounjaro

Xu H, Sun Y, You B, Huang C-P, Ye D, Chang C

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Metabolic Pharmaceuticals Phase IIb obesity program completed but did not advance to registration