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This allows researchers to isolate metabolic signaling effects without confounding endocrine responses, making AOD 9604 a useful model for studying localized metabolic regulation

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Thus, depletion of intracellular GSH is considered a potential solution to boost the efficacy of chemotherapy and ROS-based therapy, including PDT, SDT, CDT, ferroptotic therapy, and radiotherapy

369 The hyper-metabolism of cancer cells causes the excessive generation of ROS

Reactive oxygen species signaling and oxidative stress: transcriptional regulation and evolution

Evidence for local versus systemic injection effectiveness remains debated