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The STEP 1 trial used 2.4 mg as the target maintenance dose and achieved average weight loss of 14.9% of body weight over 68 weeks

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This includes individuals with medical conditions such as pernicious anemia, atrophic gastritis, celiac disease, or Crohns disease, all of which can interfere with B12 absorption

The team did find that over time, symptoms in patients with lower B12 levels developed more rapidly than those with higher levels: Patients with lower B12 levels had a significantly reduced ambulatory capacity than patients with higher levels

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