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Effectiveness and evidence The strongest, most reproducible evidence for weight loss comes from prescription injectable GLP-1 therapies like semaglutide and tirzepatide, with multiple large randomized trials showing significant weight reduction and metabolic benefits
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The idea for the study initially bubbled up during a Fralin Biomedical Research Institute faculty retreat and was led by Warren Bickel, professor and director of the Addiction Recovery Research Center, who died in 2024
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