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In the Phase 2 obesity trial, the 12 mg weekly dose produced a mean weight reduction of about 24.2% at 48 weeks ( Jastreboff et al., NEJM 2023 ) the largest figure reported for any single agent in the incretin class at the time

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10.1021/acsnano.8b06201 76 ShiM.FortinD.PaquetteB.SancheL

Lean mass stabilized between months 712, with an overall ~3 kg loss

Seek medical advice if sulphur burps persist beyond the first 8-12 weeks of treatment or worsen over time despite dietary modifications

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