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Small studies showed promising outcomes, such as lower A1c levels and less insulin needed

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doi:10.1136/postgradmedj-2019-137186

Michael Somenek, a clinical investigator in the groundbreaking Galderma study, notes that as medication-driven weight loss becomes more prolific around the world, so do the associated impacts of facial volume loss and other unwanted cosmetic effects like shadowing and hollowness. The Science Behind Facial Changes with GLP-1 Medications The 2025 Galderma clinical trial confirms what weve been observing in our practice at Aestha Clinic

But when her team analyzed the FDA Adverse Event Reporting System (FAERS) a post-marketing surveillance database where patients, caregivers and clinicians voluntarily report potential side effects they found that some people taking GLP-1 receptor agonists reported parosmia, a smell distortion disorder in which familiar scents suddenly smell "wrong," and often unpleasant