2.4.2 CHAC1 in neuroprotection and organ injury Similar to its role in stem cell fate, CHAC1/BOTCH exhibits a dual function in regulating neuroprotection and inflammation following neuronal damage and organ injury
Currently, bacteriophage therapy is the only alternative as effective as antibiotics
However, elevated MMA and homocysteine concentrations may persist in patients with cobalamin concentrations between 200 and 350 pg/mL
(2015) Five Chinese patients with 5-oxoprolinuria due to glutathione synthetase and 5-oxoprolinase deficiencies, Brain Dev
Modulating skin colour: role of the thioredoxin and glutathione systems in regulating melanogenesis
Within this mechanistic framework, natural compounds with antioxidant and anti-inflammatory properties, including vitamins C and E, glutathione precursors, CoQ10, L-carnosine, polyphenols including quercetin, resveratrol, and curcumin, and saffron metabolites like crocin and safranal show biological plausibility and preliminary efficacy on biochemical and behavioral endpoints