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Research schedules vary, but typical models use once-weekly dosing for up to 1216 weeks depending on study design
This phenomenon is thought to result from compensatory mechanisms, such as increased SGLT1 activity and upregulation of SGLT2 expression
10.1152/ajpgi.00511.2010 116
The practical answer: there is no established maximum safe duration yet
Editor recognition statement Handling editor: Ananya Rastogi, in collaboration with the Nature Computational Science team
These medications emulate the action of GLP-1, a key hormone released during food intake that contributes to feelings of a state of fullness or leaves you more satiety
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