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Side Effects Common Headache Nausea, vomiting Abdominal pain Constipation or diarrhea Bloating / flatulence Long-Term or Serious Vitamin B12 deficiency Hypomagnesemia Increased risk of fractures (hip, spine, wrist) Kidney injury (interstitial nephritis) C

Summarizing all studies, Sarlis et al

To date, the presence of GLP-1R in the renal vasculature has been confirmed but not in the tubules ( Oxidative Stress/Inflammation GLP-1RAs have been shown to prevent renal oxidative stress by inhibiting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase through the activation of PKA and the production of cyclic adenosine monophosphate (cAMP)

Brauer R, Wei L, Ma T, Arah OA, Nielsen J, Mellemkjaer L, et al

2017 02;40(2):e26