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What Do We Know About GLP-1s in Pregnancy

(2021) 19:e3001271

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Abbreviations ADVANCE: action in diabetes and vascular disease AMI: acute myocardial infarction BID: twice daily bpm: beats per minute CI: confidence interval CVOT: cardiovascular outcome trial ELIXA: Evaluation of LIXisenatide in Acute coronary syndrome FIGHT: Functional Impact of GLP-1 for Heart Failure Treatment GLP-1 RA: glucagon-like peptide-1 receptor agonist HF: heart failure HR: heart rate LAR: long-acting release LEADER: Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results LIVE: Effect of LIraglutide on left VEntricular function in chronic heart failure patients with and without type 2 diabetes LS: least squares PK: pharmacokinetic QD: once daily QW: once weekly SE: standard error T2DM: type 2 diabetes mellitus References Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, Peters AL, Tsapas A, Wender R, Matthews DR

Both drug classes were equally effective in reducing combined major adverse cardiac events such as heart attack, stroke, and death from cardiovascular disease, compared to people with diabetes who were not taking the drugs.[3] The rate of hospitalization for heart failure was 32% less in patients taking SGLT2 inhibitors compared to patients not taking the drugs, especially in those with more severe cardiovascular disease risk

The US list price sits around $1,027 per month per Novo Nordisk, and KFF puts the comparison US figure at $936, versus about $93 in the United Kingdom, $83 in France, $103 in Germany, $147 in Canada, and $169 in Japan for the same brand Ozempic