Despite advances in chemotherapy, radiotherapy, and targeted therapies, challenges such as poor drug accumulation, systemic toxicity, and multidrug resistance persist, partly due to elevated intracellular GSH levels that neutralize reactive therapeutics and reduce treatment response
So this is very much evolving in real time
Due to the active metabolism of neurons, the demand for oxygen is high and a large number of ROS are produced
The American Diabetes Association recommends proactive dose adjustments and increased glucose monitoring
It is a process that demands careful consideration and planning so that adverse effects are reduced while ensuring that blood sugar levels remain stable and within normal limits
Jastreboff AM, Kaplan LM, Fras JP, Wu Q, Du Y, et al