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To determine dose level and dose frequency of central administration of mGIPR-Ab, pharmacokinetic profile of ( a ) brain and ( b ) plasma exposure was assessed at 4, 24, 72, 120, and 168 h following a single ICV injection of 15 g/L/mouse dose of mGIPR-Ab
Neurobehavioral Impact : Influences oxytocin pathways, enhancing social behavior and impulse control 4
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9 Nausea that is not following the expected pattern
47 These symptoms are due to the drugs mechanisms of action, particularly delayed gastric emptying, and are the primary reason for treatment discontinuation, representing a major barrier to adherence
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