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Their increase induces endothelial lesions and the oxidation of LDL and redox-sensitive genes, reaching the monocyte-1 chemo attracting protein and the vascular cell adhesion molecules, molecular mechanisms that are involved in the development of the atherosclerosis

That is, the top-left panel, depicting the back skin tissue from untreated wild-type (WT control) mouse, shows a partial duplication with the image from the KAT8 inhibitor treatment group (specifically, the top-right panel of Figure 2F, KAT8-inhibitor control group)

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However, it should not be applied on open wounds or broken skin

In contrast, however, another study concluded that the activity of APE1 was reduced in sALS patients (Kisby et al., 1997)