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In line with these results, we detected lower CI activity in total lysates of Gclc -deficient FoB compared to control FoB (Fig
Jenkins DJA, Kitts D, Giovannucci EL, Sahye-Pudaruth S, Paquette M, Blanco Mejia S, et al
Low GSH in aging is associated with lower intake of GSH precursors, mainly cysteine, and lower GSH synthesis evidencing diminished function of nuclear factor erythroid 2related factor 2 (Nrf2)-dependent inductive mechanisms that enhance glutamate cysteine ligase expression, rate limiting factor for the synthesis of GSH (McCarty and DiNicolantonio, 2015)
Following an important breakthrough that showed the feasibility of lactobionic acid (LBA) production in CW-based medium (Alonso et al
Carr, and S
In addition, glutamine starvation triggers the impairment of the cystine/glutamate antiporter system and decreases glutathione levels in the cell [13]
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