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Abbreviations HCC: Hepatocellular carcinoma ROS: Reactive oxygen species MCs: Mitochondrial carriers MPCs: Mitochondrial pyruvate carriers ABC: ATP-binding cassette transporters MCCs: Mitochondrial citrate carriers MCUs: Mitochondrial Ca 2 uniporters GSH: Glutathione TCGA: The Cancer Genome Atlas ICGC: International Cancer Genome Consortium HCCDB: Hepatocellular Carcinoma Database KM: KaplanMeier LASSO: Least absolute shrinkage and selection operator ROC: Receiver operating characteristic t-SNE: t -distributed stochastic neighbor embedding scAtlasLC: Single-cell Atlas in Liver Cancer UMAP: Uniform manifold approximation and projection siRNA: Target small interfering RNA LCMS/MS: Liquid chromatography-tandem mass spectrometry KEGG: Kyoto Encyclopedia of Genes and Genomes GO: Gene Ontology GSEA: Gene set enrichment analysis CCK8: Cell counting kit-8 MMP: Mitochondrial membrane potential mPTP: Mitochondrial permeability transition pore NAC: N-acetyl-L-cysteine References Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al

Reduced oxidative load, improved hydration and support for collagen-related processes contribute to a fresher, more radiant complexion

Cost-Benefit Analysis While copper peptides may initially seem more expensive than basic anti-wrinkle creams or home remedies, they often provide better value when considering: Multi-targeting Approach: A single copper peptide product can address multiple aging concerns, potentially replacing separate products for firming, antioxidant protection, and repair

Eur J Pharm Res

Zhang Y, He C, He Y, et al

Glutathione and glycolic acid are potent antioxidants that balance oxidative stress caused by free radicals, while shea butter is an efficient moisturizer that increases antioxidants efficiency and maintains skin hydration