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4 Adverse events in PIONEER 3 1,4 Comparator AE rates are not an adequate basis for comparison of safety between products 1 Because clinical trials are conducted under widely varying conditions, AE rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice 1 AE=adverse event

doi: 10.1016/j.jep.2014.09.049

doi: 10.1111/dom.12685 22 FismanEZTenenbaumA

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Safety Profile: What Research Shows About Combining Them No published clinical trials have documented serious adverse interactions between ashwagandha and semaglutide or other GLP-1 medications