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Patients with indicators of high-risk or established ASCVD, chronic kidney disease, or heart failure According to the ADA, when considering an agent for add-on to metformin background therapy, the first recommended consideration is whether or not the patient has indicators of high-risk or established ASCVD, chronic kidney disease (CKD), or heart failure ( Figure 2 )

During the weight loss phase changes in food selection, reduction in appetite, and changes in gastrointestinal hormone levels are known to play a significant role [3]

Especially, liraglutide as one the main GLP1-Ras by reducing mean BMI and body weight percentage affects improving WL outcomes

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