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The authors hypothesize that HLA binding pockets have co-evolved with the naturally occurring amino acids and that most unnatural amino acids will be less well adapted to HLA binding than their naturally occurring proxies
doi: 10.1023/A:1018863716749 160 SchirraJHouckPWankUArnoldRGkeBKatschinskiM
Strand E, Pedersen ER, Svingen GF, et al
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