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Situations where peptide therapy is typically deferred or used cautiously include pregnancy, breastfeeding, history of certain cancers, uncontrolled autoimmune disease, severe liver or kidney disease, and active eating disorders

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In summary, smart responsive multifunctional nanoplatforms achieve multiple objectives by regulating the tumor microenvironment: reducing hypoxia, depleting GSH to disrupt redox homeostasis, and reshaping the immune microenvironment