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The consensus statement recommends GLP-1/GIP therapy for: Adults with T1D who have overweight or obesity (BMI of 30 or higher, or 27 or higher with other health conditions) Adults with T1D who arent hitting their blood sugar goals with insulin alone, even at a healthy weight Teens and young adults with T1D who have overweight or obesity and arent reaching their targets on insulin or who are meeting targets but might still benefit If your BMI drops below 25, or was 25 or under when treatment started, your healthcare provider should check in regularly and may pause or stop the medication altogether

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[8] Once activated, these G-proteins may stimulate the production of second messengers like cAMP or IP3, which appear to act as secondary signaling molecules, potentially further propagating the signal within the cell

However, some people prefer a slower titration (increasing every 23 weeks instead) to minimize side effects, which extends the timeline to 56 months