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5-HT 4 receptor agonists Prucalopride, a selective 5-hydroxytryptamine 4 (5-HT 4 ) receptor agonist, was effective in improving symptoms in a cohort with predominantly idiopathic gastroparesis, but despite accelerating gastric emptying in a diabetes-specific group, did not improve symptoms [73]

Such results are consistent with growing evidence that alternate ligands for GPCRs exhibit biased agonism

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