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Bipolar disorder: A landmark RCT (n=75) found that NAC (1,000 mg twice daily for 24 weeks) produced a significant improvement in depression scores (Montgomery-Asberg Depression Rating Scale) in bipolar disorder as an adjunct to usual treatment (Berk et al., Biol Psychiatry, 2008) [74]

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However, the blue oral pigmentation seen with long-term minocycline therapy actually represents insoluble salts of the metabolic degradation of the drug

It can help control appetite by slowing stomach emptying and improving satiety

Patients with pre-existing diabetic retinopathy should be aware that rapid improvements in blood glucose control may be associated with temporary worsening of retinopathy, particularly with semaglutide

Skipping rinsing usually does not cause serious problems