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10.1016/j.ejpain.2008.03.003 31 HinoshitaF.OguraY.SuzukiY.HaraS.YamadaA.TanakaN.et al (2003)

This was evidenced biochemically, micro- and macroscopically

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Consequently, inhibition of TXN, TrxR and NADPH can lead to inhibited glutathione uptake, reduced GPX4 levels, increased levels of peroxides and oxidised proteins, and ultimately to iron-mediated cell death

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So I look at soft plaque as being a reversible condition and then with lipid lowering and other lifestyle measures, then we can help mitigate and lower peoples risk of developing heart disease