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Abbreviations BBD: Box-Behnken design BSA: Bovine serum albumin DTNB: (5,5-dithiobis-(2-nitrobenzoic acid) GPx: Glutathione peroxidase GSH: Reduced glutathione GSSG: Oxidized glutathione LOD: Limits of detection LOQ: Limits of quantitation RSM: Response surface modeling TBuOOH: Tert-Butyl hydroperoxide TNB: Nitro-2-thiobenzoate anion WSAVA: World Small Animal Veterinary Associations References Ademi M (2023) The role of ionized water and its impact on the activity of glutathione peroxidase on rats blood serum during hyperthermic stress

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Experimental models of intrauterine infection have revealed the role of the inflammatory response in the alteration of fetal neuronal morphology 8 , changes in oligodendrocyte precursors 9 , reduction of oligodendrocyte number, hypomyelination of brain 10 and a decrease of dopaminergic and serotoninergic neurons in offspring 11

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