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Changes are subtle in the early days

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When p53 transcriptional activity in response to 5-FU treatment was measured, the mRNA and protein levels of p21, which is a p53 target gene, were decreased in the GST WT -p53-expressing cells

So some believe that taking antioxidants should help the disease, and many dermatologists recommend this for their patients

Stay at the current dose for an additional one to two weeks before increasing