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Alexander Weber, an orthopedic surgeon and chief of sports medicine at the University of Southern California who has published a review of the evidence

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Remarkably, all 12 patients reported significant improvement in symptoms and none reported adverse effects in the short term

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(dpcj.org) Yes reported severe adverse events (e.g., SJS, SIRS) have occurred after combined IV formulations

Collagen and Elasticity Collagen and elastin are the proteins that keep skin smooth and firm but they are highly vulnerable to free radical damage