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The compounding industry argued, not unreasonably, that the restrictions had driven patients toward unregulated gray-market sources: overseas chemical suppliers operating under "research use only" labels with no quality controls, no dosage verification, and no pharmaceutical oversight

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Therefore, polyphenols can also influence the epigenetic status within cells by regulating ROS levels, thereby affecting the progression of neurodegenerative diseases [156, 157]

Severe deficiency may lead to anaemia or nerve damage

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However, the authors noted that larger clinical trials would help validate these findings