Thiol redox status regulate MPT and enhanced ROS generation can target critical cysteine residues in cyclophilin D, implying that mGSH depletion would favor MPT via redox pathways targeting MPT components
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Standard osteoporosis interventions (bisphosphonates, denosumab, teriparatide) target osteoclast inhibition or systemic bone turnover
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& Fuller, R
Corsini EM, Mitchell KG, Sceusi EL, Mehran RJ, Rice DC, Sepesi B, Walsh GL, Swisher SG , Roth JA, Vaporciyan AA, Hofstetter WL, Antonoff MB